Academic Editor: Michael H. Dahan
Background: Preterm premature rupture of membranes (PPROM) is a major
cause of preterm birth. There are few reports on vitamin D deficiency associated
with PPROM. We aimed to investigate the association between PPROM and vitamin D
levels in maternal plasma and the umbilical cord blood of newborns.
Methods: This prospective study included 355 pregnant women who
delivered live infants between March 2017 and December 2018 at a medical center.
Vitamin D levels were measured in the maternal plasma at the first, second, third
trimesters of pregnancy and just before delivery, and in the umbilical cord blood
of newborns at birth. In addition, we evaluated the pregnancy and neonatal
outcomes according to vitamin D status. Results: The rate of PPROM in
the vitamin D deficiency group (25(OH)D