IMR Press / CEOG / Volume 49 / Issue 5 / DOI: 10.31083/j.ceog4905101
Open Access Original Research
Perinatal Risk Factors for the Development of Neonatal Intraventricular Hemorrhage in Preterm Infants
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1 Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, 216-8511 Kawasaki, Japan
*Correspondence: (Junichi Hasegawa)
Academic Editors: Michael H. Dahan and Jacques Balayla
Clin. Exp. Obstet. Gynecol. 2022, 49(5), 101;
Submitted: 21 January 2022 | Revised: 27 February 2022 | Accepted: 8 March 2022 | Published: 26 April 2022
(This article belongs to the Section Pregnancy)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background: To evaluate the impact perinatal factors closely related to the development of neonatal intraventricular hemorrhage (IVH) in preterm infants. Methods: A retrospective case-control study was performed on premature infants born in our perinatal center in 2014–2018. Neonates with IVH were age-matched with normal controls (1:5). Perinatal factors were compared between cases and controls. Results: Fourteen cases and 70 controls had a median of 26.5 (range 22–29) weeks gestational age. Significant difference was observed regarding the incidence of clinical chorioamnionitis (43% and 14%, p = 0.023) and the use of magnesium sulfate (MgSO4) (14% and 51%, p = 0.017). Adjusted odds ratios (95% confidence interval) were 8.3 (1.8–38) in clinical chorioamnionitis and 0.15 (0.03–0.76) in magnesium sulfate. Conclusions: Relevant perinatal factor of IVH in premature infants born before 30 weeks of gestation was strongly associated with clinical chorioamnionitis. Furthermore, MgSO4 exposure suggested a neuroprotective effect against IVH.

intraventricular hemorrhage
magnesium sulfate
perinatal care
risk factor
Fig. 1.
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