Academic Editor: Michael H. Dahan
Background: The incidence of postoperative nausea and vomiting (PONV)
when intrathecal morphine (ITM) is used for caesarean delivery (CD) is up to 80%
without antiemetic prophylaxis. Prophylactic antiemetics can reduce this rate by
50%, except for dexamethasone that did not show to be effective in this context.
Combinations showed divergent results. We investigated the incidence of PONV when
different combinations of antiemetics were used for CD in parturients receiving
ITM. Methods: Retrospective, single centre cohort study of patients
undergoing elective CD with ITM between January 2016 and October 2017. The
primary outcome was the incidence of PONV requiring treatment in the first 24
hours following CD. Interactions were sought using multivariate modelling for
predictors of PONV following surgery. Results: Overall, 598 women were
included in the study. The rate of PONV requiring treatment was 29.1%. The rate
of PONV decreased with increasing numbers of prophylactic medications (p