Background: To assess the associations between vanishing gestational age
and the adverse perinatal outcomes following in vitro fertilization
cycles. Methods: This is a retrospective cohort study conducted in
Guangzhou Women and children hospital from January 2011 to January 2019. We
identified 350 vanishing twin pregnancies including 54 secondary fetal deaths and
296 singleton deliveries compared to 2080 infants from single gestations. The
children detected by transvaginal ultrasonography in gestational week 6. By
linking with the hospital’s registries, the main endpoints were gestational age
(weeks), birth weight (g), low birth weight (LBW), preterm birth and neonatal
malformation rate. Perinatal outcomes were compared among study groups and
controls. Results: Of the 350 vanishing twin, there were 15.4% (54)
secondary fetal death. Of the 2376 singleton deliveries, 12.5% (296) originated
from a twin gestation. In the assessment of perinatal outcome, there were no
significant differences between the singleton cohort and vanishing twin before
the presence of fetal cardiac activity cohort (VT before CA) and early vanishing
cohort. The late vanishing twin group had a higher risk of preterm delivery
(P
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Open Access
Original Research
Vanishing twin after 12 gestational weeks is associated with adverse perinatal outcomes in in vitro fertilization cycles
Jun Liu1,†, Chun-Lin Liu1,†, Qinhong Luo1, Zhufeng Wu1, Fengxiang Li1, Dongyi Chen1, Chaoyan Li1, Ling Sun1,*
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1
Department of Assisted Reproductive Technology, Guangzhou Women and Children’s Hospital, 510515 Guangzhou, Guangdong, China
Clin. Exp. Obstet. Gynecol. 2022, 49(2), 34;
https://doi.org/10.31083/j.ceog4902034
Submitted: 14 March 2021 | Revised: 7 July 2021 | Accepted: 21 July 2021 | Published: 8 February 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract
Keywords
In vitro fertilization
IVF
Perinatal outcome
Vanishing twin
VT
Figures
Fig. 1.