Academic Editor: Michael H. Dahan
Background: It has been suggested that hypovitaminosis D is associated
with the development of preeclampsia. This study aimed to study the relationship
between preeclampsia and various vitamin D serum biomarkers including 25-hydroxyl
vitamin D [25(OH)D], vitamin D-binding protein (VDBP), and bioavailable and free
25(OH)D. Methods: This prospective study was conducted with 17 patients
with preeclampsia and 38 normal pregnant women as the control group. Total serum
25(OH)D and VDBP concentrations were measured. The levels of bioavailable 25(OH)D
and free 25(OH)D were also calculated. Two single nucleotide polymorphisms
(rs4588 and rs7041) of the GC gene encoding VDBP were analyzed.
Results: VDBP was significantly increased in the preeclampsia group
compared to the normal pregnancy group (454.2 vs. 403.4 ng/mL; p =
0.036). When the preeclampsia patients were analyzed by dividing them into
early-onset and late-onset, there was no significant difference in the serum
vitamin D biomarkers levels. Also, when preeclampsia patients were classified
into three subgroups of