IMR Press / CEOG / Volume 49 / Issue 10 / DOI: 10.31083/j.ceog4910214
Open Access Original Research
Maternal Plasma Elabela, a Biomarker for the Severity and Kidney Function of Human Preeclampsia
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1 Department of Ultrasound, the Second Affiliated Hospital, Xi'an Jiaotong University, 710004 Xi'an, Shaanxi, China
2 Department of Obstetrics and Gynecology, the Second Affiliated Hospital, Xi'an Jiaotong University, 710004 Xi'an, Shaanxi, China
*Correspondence: qyhhlf@163.com (Yanhua Qi)
These authors contributed equally.
Academic Editor: Paolo Ivo Cavoretto
Clin. Exp. Obstet. Gynecol. 2022, 49(10), 214; https://doi.org/10.31083/j.ceog4910214
Submitted: 29 March 2022 | Revised: 8 June 2022 | Accepted: 15 June 2022 | Published: 20 September 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Background: It reported that serum Elabela level was decreased in preeclampsia patients. However, there is no researcher done the study on the correlations between plasma Elabela and kidney function, blood pressure, blood glucose and lipid in preeclampsia patients. Our objective is determined whether plasma Elabela could be a marker for the severity and kidney function of preeclampsia. Methods: 72 pregnant women were enrolled in this study and divided into healthy group (n = 37), mild preeclampsia group (n = 20) and severe preeclampsia group (n = 15). The level of plasma Elabela was detected using ELISA. Results: Plasma Elabela was reduced in preeclampsia patients compared to healthy group, and severe preeclampsia patients had the lower level of Elabela and poorer kidney function. The level of plasma Elabela was negatively correlated with those of uric acid (UA), creatinine (Cre), cystatin C (CysC), systolic blood pressure (SBP) and diastolic blood pressure (DBP). Conclusions: Lower concentration of plasma Elabela correlated with worse kidney function, and higher blood pressures in preeclampsia patients.

Keywords
biomarker
blood pressure
Elabela
kidney function
preeclampsia
Funding
2018D061/Health Commission of Shaanxi province
2021SF-134/Key R & D projects of Shaanxi Province
2021SF-001/Key R & D projects of Shaanxi Province
2020SF-057/Key R & D projects of Shaanxi Province
Figures
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