Background: The signs and symptoms of the genitourinary syndrome of
menopause are well established, and there is extensive knowledge with high
scientific evidence about the response that vaginal and urinary tissues present
to various treatments. However, this does not usually apply to the vulva in
general, or any of its structures in particular, since it is included in the term
vulvovaginal. The aim of this review is to improve knowledge about the vulva and
to improve symptoms in women who experience vulvar pain associated with atrophy.
Methods: The study was registered at PROSPERO (registration number
CRD42020172102). We also assessed the quality of evidence for each outcome of
interest according to the GRADE criteria. Results: We systematically
reviewed eight studies: four with ospemifene, a pilot study with prasterone, a
study using a combination of estrogens and androgens, another study that used
CO
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Open Access
Systematic Review
Treatment of vulvar pain caused by atrophy: a systematic review of clinical studies
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1
Gynecology and Obstetrics Department, General University of Catalunya, Sant Cugat del Vallès, 08195 Barcelona, Spain
2
Gynecology and Obstetrics Department, Miguel Servet University Hospital, 50009 Zaragoza, Spain
3
Gynecology and Obstetrics Department, Granada University, 1816 Granada, Spain
*Correspondence: nicomendoza@telefonica.net (Nicolás Mendoza)
Clin. Exp. Obstet. Gynecol. 2021, 48(4), 800–805;
https://doi.org/10.31083/j.ceog4804128
Submitted: 4 April 2021 | Revised: 26 May 2021 | Accepted: 28 May 2021 | Published: 15 August 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract
Keywords
Vulvar atrophy
Vulvar pain
Sexual health
Genitourinary syndrome of menopause
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