IMR Press / CEOG / Volume 39 / Issue 3 / pii/1630480840073-198483811

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
Effects of tamoxifen and raloxifene on body and uterine weights of rats in persistent estrus
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1 Department of Gynecology, Piaui Federal University, Teresina, Piaui (Brazil)
Clin. Exp. Obstet. Gynecol. 2012, 39(3), 362–364;
Published: 10 September 2012
Abstract

Purpose: To evaluate the change in body and uterine weights of rats in persistent estrus, a model developed to mimic polycystic ovary syndrome treated with selective estrogen receptor modulators (SERMs) tamoxifen and raloxifene. Methods: Sixty Wistar- Hannover rats induced by a single subcutaneous dose of 1.25 mg testosterone propionate were divided into three groups of 20 animals: Group I (placebo); Group II (tamoxifen, 250 μg/day) and Group III (raloxifene, 750 μg/day). At 90 days of life, the treatment began for 30 consecutive days, in which the animals were weighed weekly. On the 31st day, the animals were sacrificed and the uterus removed. Data were analyzed statistically by analysis of variance and by the Tukey-Kramer multiple comparisons test (p < 0.05). Results: Means of body and uterine weights (g) after treatment were: 227.3 ± 2.20 and 0.40 ± 0.01; 185.3 ± 2.45 and 0.25 ± 0.01; 186.4 ± 2.20 and 0.27 ± 0.01 in Groups I, II and III, respectively (p < 0.001). There was no statistical difference between groups II and III for body and uterine weight (p = 0.727 and p = 0.646, respectively). Conclusion: The present results indicate that, at the doses and during the time of treatment used, both tamoxifen and raloxifene reduce in a similar way the body and uterine weights of rats in persistent estrus showing a possible antiestrogenic effect of SERMs under high levels of estrogens.
Keywords
Animal models
Estrogen
Tamoxifen
Raloxifene
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