IMR Press / CEOG / Volume 33 / Issue 2 / pii/2006022

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research

Estrogen effects on the vaginal pH, flora and cytology in late postmenopause after a long period without hormone therapy

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1 Obstetrics Department, Federal University of Mato Grosso do Sul, Escola de Medicina de Mato Grosso do Sul (Brazil)
2 Gynecology Department, Federal University of Siio Paulo, Esco/a Paulista de Medicina, S如Paulo (Brazil)
Clin. Exp. Obstet. Gynecol. 2006, 33(2), 85–89;
Published: 10 June 2006
Abstract

In this report we evaluated the action of conjugated equine estrogens (CEE) on vaginal symptoms, cytology, pH, and flora in late postmenopausal women without any previous hormone therapy. The study was a randomized, double-blind, placebo-controlled trial with 48 late postmenopausal women who received placebo or unopposed CEE (0.625mg/day of CEE orally) during three months of treatment. Vaginal and sexual complaints were evaluated through daily diary cards. We analyzed vaginal changes through cytology and pH measurements. After three months of treatment, 20% of placebo-treated patients and 80% of the CEE-treated patients reported improvement in vaginal dryness and irritation. In the latter group, the vaginal cells and Lactobacillus increased and the vaginal pH decreased, without other changes in sexual complaints. We concluded that estrogen ameliorated the genital tract of late postmenopausal women without any previous hormone therapy.

Keywords
Estrogen
Menopause
Vagina
Cytology
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