IMR Press / CEOG / Volume 26 / Issue 3-4 / pii/1999045

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Intramuscular versus vaginal administration of progesterone for luteal phase support after in vitro fertilization and embryo transfer. A comparative randomized study

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1 EFRA Italy (European Fertility Research Associates), Center of Human Reproduction (Italy)
2 EFRA Italy (European Fertility Research Associates), Head of Center of Human Reproduction, Messina (Italy)
Clin. Exp. Obstet. Gynecol. 1999, 26(3-4), 203–206;
Published: 10 September 1999

A total of 156 patients were randomly treated with exogenous natural progesterone (intramuscularly, 50 mg/day) and vaginal gel (90 mg/day) P or nothing (Controls) from the day before embryo transfer (ET) for two weeks, In case of positivejJ-HCG, the treat­ment was continued for 12 weeks, Plasma P and 17 β-Estradiol concentrations were estimated and compared with the control not supplemented group Both treatments were able to increase significantly the luteal plasmatic values of P versus controls, The ongoing pregnancy and the living birth rates per transfer were significantly higher in the patients supplemented with intra muscular P than in those treated with vaginal gel P, The intramuscular natural P appears the most suitable route of administration for luteal phase support in IVF-ET procedures.

Intramuscular progesterone
Vaginal gel progesterone
Luteal phase supplementation
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