Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Intramuscular versus vaginal administration of progesterone for luteal phase support after in vitro fertilization and embryo transfer. A comparative randomized study
A total of 156 patients were randomly treated with exogenous natural progesterone (intramuscularly, 50 mg/day) and vaginal gel (90 mg/day) P or nothing (Controls) from the day before embryo transfer (ET) for two weeks, In case of positivejJ-HCG, the treatment was continued for 12 weeks, Plasma P and 17 β-Estradiol concentrations were estimated and compared with the control not supplemented group Both treatments were able to increase significantly the luteal plasmatic values of P versus controls, The ongoing pregnancy and the living birth rates per transfer were significantly higher in the patients supplemented with intra muscular P than in those treated with vaginal gel P, The intramuscular natural P appears the most suitable route of administration for luteal phase support in IVF-ET procedures.