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Vaginal administration of gemeprost for preoperative cervical dilatation in non pregnant patients
P. Martinelli1, M. Locci1, T. Guerritore1, F. Arpaia1, G. Di Meglio1, A. Giannitelli1, P. C. Latorre1, U. Montemagno1
1 Istituto di Ginecologia, Ostetricia e Fisiopatologia della Riproduzione Umana II Facolta di Medicina e Chirurgia - Universita degli Studi di Napoli (Italy)
1 Istituto Farmacologico Serono - Roma (Italy)
Clin. Exp. Obstet. Gynecol. 1989, 16(2-3), 61–64;
Published: 10 June 1989
The use of Gemeprost vaginal suppositories has been evaluated in a trial for in-duction of the cervical dilatation in non-pregnant women. 30 voluntary patients, 22 nulliparous and 8 pluriparous, had to be subjected to biopsy of the endometrium; 24 were treated for the control of sterility and 6 for menstrual perimenopausal di-sorders. The biopsies of the sterility control were effected in the second half of the cycle, generally without having recourse to narcosis. A single Gemeprost pessary containing 1 mg of 16, 16-dimethyl-trans- PGE, methyl ester was intravaginal administered, deeply into the posterior fornix, 3 hours before the biopsy. All the observed side effects presented a modest intensity: cephalalgia 6.6% (no. 2), gastral-gia 3.3% (no. 1), vaginal burning 6.6% (no. 2). No significant variation of vital function para-meters was recorded. In conclusion this type of preparation of the cervix has permitted us to achieve a more gra-dual dilatation and to prevent the traumata of the cervico-isthmic system due to forced mecha-nical dilatataions by the exclusive use of Hegar’s dilators.