Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Vaginal administration of gemeprost for preoperative cervical dilatation in non pregnant patients
P. Martinelli 1, M. Locci 1, T. Guerritore 1, F. Arpaia 1, G. Di Meglio 1, A. Giannitelli 1, P. C. Latorre 1, U. Montemagno 1
Affiliations
Article Info
1 Istituto di Ginecologia, Ostetricia e Fisiopatologia della Riproduzione Umana II Facolta di Medicina e Chirurgia - Universita degli Studi di Napoli (Italy)
1 Istituto di Ginecologia, Ostetricia e Fisiopatologia della Riproduzione Umana II Facolta di Medicina e Chirurgia - Universita degli Studi di Napoli (Italy)
Abstract
The use of Gemeprost vaginal suppositories has been evaluated in a trial for in-duction of the cervical dilatation in non-pregnant women. 30 voluntary patients, 22 nulliparous and 8 pluriparous, had to be subjected to biopsy of the endometrium; 24 were treated for the control of sterility and 6 for menstrual perimenopausal di-sorders. The biopsies of the sterility control were effected in the second half of the cycle, generally without having recourse to narcosis. A single Gemeprost pessary containing 1 mg of 16, 16-dimethyl-trans- PGE, methyl ester was intravaginal administered, deeply into the posterior fornix, 3 hours before the biopsy. All the observed side effects presented a modest intensity: cephalalgia 6.6% (no. 2), gastral-gia 3.3% (no. 1), vaginal burning 6.6% (no. 2). No significant variation of vital function para-meters was recorded. In conclusion this type of preparation of the cervix has permitted us to achieve a more gra-dual dilatation and to prevent the traumata of the cervico-isthmic system due to forced mecha-nical dilatataions by the exclusive use of Hegar’s dilators.