Dear Colleagues,

Epithelial ovarian cancer (EOC) remains one of the most lethal gynecological malignancies. Despite significant progress in medical research, the high mortality rate associated with EOC persists, primarily due to late - stage diagnosis and limited treatment options. This special issue aims to bring together the latest research findings, innovative diagnostic techniques, and novel treatment strategies to address epithelial ovarian cancer.

Research Areas Covered

Diagnostic Advances

New biomarker discovery: Identification of novel protein, genetic, or epigenetic biomarkers for early detection, prognosis prediction, and treatment response monitoring of EOC.

Imaging techniques: Advancements in ultrasound, magnetic resonance imaging (MRI), positron emission tomography - computed tomography (PET - CT), as well as other imaging modalities for accurate tumor localization, staging, and assessment of treatment efficacy.

Liquid biopsy: The use of circulating tumor cells (CTCs), cell - free DNA (cfDNA), and exosomes in blood, urine, or other body fluids for non - invasive diagnosis and disease monitoring.

Treatment Strategies

Surgical innovations: Minimally invasive surgical approaches, such as laparoscopic and robotic - assisted surgery, and their impact on patient outcomes, including reduced morbidity, shorter hospital stays, and improved quality of life.

Chemotherapy: Novel chemotherapeutic agents, combination therapies, and personalized chemotherapy regimens based on patient - specific genetic and molecular profiles.

Targeted therapy: The development and application of drugs targeting specific molecular pathways, such as angiogenesis inhibitors, poly (ADP - ribose) polymerase (PARP) inhibitors, and immune - checkpoint inhibitors, in the treatment of EOC.

Immunotherapy: Immunotherapeutic strategies, including cancer vaccines, adoptive cell transfer, and immune - checkpoint blockade, and their potential to enhance the body’s immune response against EOC.

Clinical Trials and Patient - Centered Care

The latest results of clinical trials evaluating new diagnostic and treatment modalities in EOC.

Patient - reported outcomes, quality - of - life assessment, and survivorship care in the context of EOC treatment.

Dr. Juan Zhou and Dr. San-Gang Wu
Guest Editors