IMR Press / FBL / Volume 5 / Issue 3 / DOI: 10.2741/somasund

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Tumor suppressor p53: regulation and function
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1 Laboratory of Molecular Oncology and Cell Cycle Regulation University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
2 Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
3 Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
4 Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
5 Department of Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Academic Editor:Xavier Grana
Front. Biosci. (Landmark Ed) 2000, 5(3), 424–437; https://doi.org/10.2741/somasund
Published: 1 April 2000
(This article belongs to the Special Issue Eukaryotic cell cycle control)
Abstract

The p53 protein is a transcription factor involved in maintaining genomic integrity by controlling cell cycle progression and cell survival. Mutations in p53 are the most frequently seen genetic alterations in human cancer. The function of p53 is critical to the way many cancer treatments kill cells because radiotherapy and chemotherapy act in part by triggering programmed cell death in response to DNA damage. Consequently, tumors which bear p53 mutations, are often difficult to treat and their prognosis is poor. Since the underlying feature of tumors with p53 mutations is the absence of functional p53, gene replacement therapy with wild-type p53 gene is being considered as an approach for treating a variety of cancers. In recent years, more information has been obtained regarding various pathways leading to the activation of p53, particularly those involving post-translational modifications of p53. Several new target genes of p53 have been identified. This review will summarize current knowledge on the structure, mechanism of activation and effectors of p53 function.

Keywords
p53
apoptosis
Cell cycle
Cancer
Tumor suppressor
p73
Review
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