IMR Press / FBL / Volume 5 / Issue 3 / DOI: 10.2741/kooten

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Immune regulation by CD40-CD40-l interactions - 2; Y2K update
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1 Dept of Nephrology, Leiden University Medical Center, Leiden, the Netherlands
Front. Biosci. (Landmark Ed) 2000, 5(3), 880–893; https://doi.org/10.2741/kooten
Published: 1 November 2000
Abstract

CD40 is a cell surface receptor, which belongs to the TNF-R family, and which was first identified and functionally characterized on B lymphocytes. However, in recent years it has become clear that CD40 is expressed much broader, including expression on monocytes, dendritic cells, endothelial cells and epithelial cells. Therefore it is now thought that CD40 plays a more general role in immune regulation. The present paper reviews recent developments in this field of research, with main emphasis on CD40 signal transduction and on in vivo functions of CD40/CD40-L interactions.

Keywords
Basic science
Immunology
CD40
CD40-L
Wignal transduction
Review
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