IMR Press / FBL / Volume 5 / Issue 3 / DOI: 10.2741/kooten

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Immune regulation by CD40-CD40-l interactions - 2; Y2K update
Show Less
1 Dept of Nephrology, Leiden University Medical Center, Leiden, the Netherlands
Front. Biosci. (Landmark Ed) 2000, 5(3), 880–893;
Published: 1 November 2000

CD40 is a cell surface receptor, which belongs to the TNF-R family, and which was first identified and functionally characterized on B lymphocytes. However, in recent years it has become clear that CD40 is expressed much broader, including expression on monocytes, dendritic cells, endothelial cells and epithelial cells. Therefore it is now thought that CD40 plays a more general role in immune regulation. The present paper reviews recent developments in this field of research, with main emphasis on CD40 signal transduction and on in vivo functions of CD40/CD40-L interactions.

Basic science
Wignal transduction
Back to top