IMR Press / FBL / Volume 12 / Issue 6 / DOI: 10.2741/2235

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article
T cell immune responses to HIV-1
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1 The Aaron Diamond AIDS Research Center, 455 First Avenue, 7th Floor, New York, New York 10016, USA
2 Laboratory of Cellular Immunology and Physiology, The Rockefeller University 1230 York Avenue, New York, New York 10021, USA
3 Current address: Department of Microbiology, Molecular Genetics and Immunology, The University of Kansas Medical Center, 3025 Wahl Hall West, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
Front. Biosci. (Landmark Ed) 2007, 12(6), 2330–2343; https://doi.org/10.2741/2235
Published: 1 January 2007
Abstract

The recent use of multiparametric flow cytometry to monitor T cell immune responses complements traditional assays, such as IFN-gamma ELISPOT, to provide more information on the functional complexity of CD4+ and CD8+ T cell immune responses induced either by natural infection, or by immunization. In this review, we provide a general background on T cell subsets, and describe the cellular immune response during natural HIV-1 infection. We then review T cell responses to current candidate HIV-1 vaccines. Taken together, this helps to formulate our understanding of the immune correlates of protection required for an effective prophylactic HIV-1 vaccine. Finally, we emphasize current dendritic cell based vaccine strategies designed to modulate immunity to establish immune protection against HIV-1.

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