IMR Press / FBL / Volume 9 / Issue 3 / DOI: 10.2741/1394

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Kaposi's sarcoma-associated herpesvirus immediate early gene activity
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1 Department of Biochemistry and Molecular Biology, The George Washington University, Washington, District of Columbia 20037, USA
2 The Institute for Genomic Research, Rockville, Maryland 20850, USA
Academic Editor:Kenneth Roebuck
Front. Biosci. (Landmark Ed) 2004, 9(3), 2245–2272; https://doi.org/10.2741/1394
Published: 1 September 2004
(This article belongs to the Special Issue Inflammatory response mechanisms)
Abstract

KSHV is the causative agent of three human proliferative disorders: Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Herpesvirus gene expression and viral replication is a complex, tightly regulated process involving latent, immediate early, early, and late viral gene transcription. The immediate early genes generally code for transcriptional activators and are critical for initiating viral transcription. KSHV encodes for approximately nine immediate early gene products, including ORF50, K8, K9, K3, K5, ORF57, ORF29b, ORF45, and K4.2. This review will address the activities of these proteins and what roles they play in virus replication, evasion of the host immune response, and viral pathogenesis.

Keywords
KSHV
HHV-8
Herpesvirus
Immediate early genes
Review
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