IMR Press / FBL / Volume 19 / Issue 5 / DOI: 10.2741/4242

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Osteoclastogenesis and osteoimmunology
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1 Shanghai Seventh People's Hospital, Shanghai, China
2 School of Rehabilitation Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
3 School of Sport Science, Shanghai University of Sport, Shanghai, China
Academic Editor:Fei He
Front. Biosci. (Landmark Ed) 2014, 19(5), 758–767;
Published: 1 January 2014
(This article belongs to the Special Issue Cellular immunology and stem cell biology)

Bone is continuously renewed through a dynamic balance between bone resorption and formation and is the fundamental basis for maintaining normal bone mass and architecture by osteoclasts (bone resorption) and osteoblasts (bone formation). Bone resorption is an elementary cellular activity in the modeling of the skeleton during growth and development. Later in life, bone remodeling occurs, and is locally initiated by resorption. During remodeling, bone resorption is coupled to new bone formation, that ensures bone renewal with only minor and temporary local bone loss. Osteoclasts play a crucial role in both physiological and pathological bone resorption, and receptor activator of nuclear factor-κB ligand is the key cytokine that induces osteoclastogenesis. At the same time, various factors produced during immune responses are capable of profoundly affecting bone regulation; bone and immune systems share an abundance of molecules and regulatory mechanisms. We summarize the new insights on the link between osteoclastogenesis and osteoimmunology.

Osteoclast; Osteoimmunology; Receptor
Activator Of Nuclear Factor-KappaB
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