IMR Press / FBL / Volume 19 / Issue 1 / DOI: 10.2741/4195

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Membranes to achieve immunoprotection of transplanted islets
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1 Therapeutic Micro and Nanotechnology Laboratory, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco (UCSF), 1700 4th Street, Box 2520, San Francisco, CA, 94158, USA
Academic Editors:Patrick Vermette, Jonathan Lakey, Rennian Wang, Steven Paraskevas
Front. Biosci. (Landmark Ed) 2014, 19(1), 49–76; https://doi.org/10.2741/4195
Published: 1 January 2014
Abstract

Transplantation of islet or beta cells is seen as the cure for type 1 diabetes since it allows physiological regulation of blood glucose levels without requiring any compliance from the patients. In order to circumvent the use of immunosuppressive drugs (and their side effects), semipermeable membranes have been developed to encapsulate and immunoprotect transplanted cells. This review presents the historical developments of immunoisolation and provides an update on the current research in this field. A particular emphasis is laid on the fabrication, characterization and performance of membranes developed for immunoisolation applications.

Keywords
Cell Immunoisolation
Cell Transplantation
Inorganic Membranes
Macrocapsules
Microcapsules
Organic Membranes
Type 1 Diabetes
Review
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