IMR Press / FBL / Volume 18 / Issue 1 / DOI: 10.2741/4107

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Prevalence and risk factor for MDR-GNB infection in liver transplantation
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1 Department of General Surgery, Shanghai First People Hospital, Medical School of Shanghai Jiaotong University,85 Wu Jing Road,200080,Shanghai, People’s Republic of China
2 Department of Urology, Shandong Province Qianfoshan Hospital, Shandong University, Jinan 250014, People’s Republic of China
3 Shandong Academy of Medical Science, Jinan 250062, People’s Republic of China
Academic Editor:Fei He
Front. Biosci. (Landmark Ed) 2013, 18(1), 366–370; https://doi.org/10.2741/4107
Published: 1 January 2013
(This article belongs to the Special Issue Cellular immunology and stem cell biology)
Abstract

Liver transplantation (LT) has emerged as a viable therapy for various end-stage liver diseases. Multi- drug resistant Gram-negative bacilli (MDR-GNB) have emerged as predominant pathogens. The prevalence of MDR-GNB infection has been increasing in LT recipients, especially in early post-LT stages. MDR-GNB infection has become a main cause of death following LT. Since key elements of MDR-GNB infection after LT mainly include the pre-LT severity of underlying disease, technical problems, acute rejection, and so on, appropriate measures, such as improvement of LT technology and management, restriction of antibiotic use and immunosuppressive therapy advancement, should be commenced to prevent and control the occurrence of MDR-GNB infection. A better understanding of the prevalence of and risk factors for MDR-GNB infection complications is needed to improve quality of life and survival rate after LT.

Keywords
Liver transplantation
Multi-Drug Resistant Gram-Negative Bacilli
Orthotopic Liver Transplantation
Review
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