IMR Press / FBL / Volume 15 / Issue 3 / DOI: 10.2741/3667

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Interactions between PrPc and other ligands with the 37-kDa/67-kDa laminin receptor

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1 School of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, Republic of South Africa (RSA)
Academic Editor:Sophie Mouillet-Richard
Front. Biosci. (Landmark Ed) 2010, 15(3), 1150–1163; https://doi.org/10.2741/3667
Published: 1 June 2010
(This article belongs to the Special Issue Cellular prion protein partners and signaling)
Abstract

The 37-kDa/67 kDa laminin receptor (LRP/LR) represents a multifunctional protein. It is a receptor for viruses such as Dengue viruses, Alphaviruses and Adeno-associated viruses (AAV), as well as the cellular prion protein (PrPc) and infectious prions (PrPSc). The 37-kDa/67-kDa LRP/LR plays furthermore fundamental roles in basic cell biological processes such as cell adhesion and cell growth and acts as a key player in metastatic cancer, affecting invasion, adhesion and apoptotic processes.  This review gives fundamental insights into basic cellular processes affected by LRP/LR including signal transduction and cell cycle progression and focuses on pathophysiological implications of the interaction of prion proteins, laminin, viruses and other ligands with LRP/LR affecting the development of highly-prevalent diseases such as cancer, neurodegenerative diseases such as prion disorders and Alzheimer's disease as well as viral infections. Molecular tools such as LRP/LR specific antibodies and siRNAs targeting LRP expression as possible alternative therapeutics for the treatment of neurodegenerative diseases, metastatic cancer and viral infections are emphasized.

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