IMR Press / FBL / Volume 15 / Issue 3 / DOI: 10.2741/3662

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Cellular roles of the prion protein in association with reggie/flotillin microdomains
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1 University of Konstanz, Department of Biology, 78457 Konstanz, Germany
Academic Editor:Sophie Mouillet-Richard
Front. Biosci. (Landmark Ed) 2010, 15(3), 1075–1085;
Published: 1 June 2010
(This article belongs to the Special Issue Cellular prion protein partners and signaling)

The prion protein (PrP) has been implicated in many diverse functions, making it difficult to pinpoint its basic physiological role. Our most recent studies in zebrafish, mammalian and invertebrate cells indicate that PrP regulates cell-cell communication, as well cell-matrix interactions at focal adhesions. In addition, we previously have shown that upon antibody-mediated cross-linking, PrP can be induced to cluster in the preformed T-cell cap. Here we review these data and discuss how the spatial link between PrP and the microdomain-forming proteins reggie-1 (flotillin-2) and reggie-2 (flotillin-1) may contribute to PrP signaling, leading to the local assembly of membrane protein complexes at sites involved in cellular communication, such as cell-cell contacts, focal adhesions, the T-cell cap, and synapses.

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