IMR Press / FBL / Volume 13 / Issue 17 / DOI: 10.2741/3182

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Role of Lgl/Dlg/Scribble in the regulation of epithelial junction, polarity and growth
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1 Laboratory for Structural Neuropathology, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako City, Saitama 351-0198, Japan
2 Department of Molecular Biology, Yokohama City University, Graduate School of Medical Science, 3-9 Fuku-ura, Kanazawa-ku, Yokohama 236-0004, Japan
Academic Editor:Andrei Ivanov
Front. Biosci. (Landmark Ed) 2008, 13(17), 6693–6707; https://doi.org/10.2741/3182
Published: 1 May 2008
(This article belongs to the Special Issue Molecular engines that build and break epithelial junctions)
Abstract

Genetic studies in Drosophila have revealed that three tumor suppressors, Discs large (Dlg), Scribble (Scrib) and Lethal giant larvae (Lgl), which localize to the basolateral region of epithelial cells, cooperatively regulate cell polarity, junction formation and cell growth in epithelial cells. Subsequent studies in Drosophila, vertebrates and C. elegans have shown the evolutionary conservation of some of their functions in epithelial cells. Also, these studies revealed the importance of antagonistic interactions between these tumor suppressors and apical polarity regulators such as Crumbs and aPKC for the establishment of apical-basal polarity with organized cell-cell junctions and regulation of cell growth in epithelial cells.

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