IMR Press / FBL / Volume 13 / Issue 10 / DOI: 10.2741/2968

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Surgical brain injury: prevention is better than cure
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1 Department of Physiology and Pharmacology, Loma Linda University Medical Center, Loma Linda, California, USA
2 Department of Neurosurgery, Loma Linda University Medical Center, Loma Linda, California, USA
3 Department of Anesthesiology, Loma Linda University Medical Center, Loma Linda, California, USA

*Author to whom correspondence should be addressed.

Academic Editor: John Zhang

Front. Biosci. (Landmark Ed) 2008, 13(10), 3793–3797;
Published: 1 May 2008
(This article belongs to the Special Issue New frontiers in neurosurgery research)

Neurosurgical procedures can cause inevitable brain damage resulting from the procedure itself. Unavoidable cortical and parenchymal incisions, intraoperative hemorrhage, brain lobe retraction and thermal injuries from electrocautery can cause brain injuries attributable exclusively to the neurosurgical operations and collectively referred to as surgical brain injury (SBI). This particular brain damage cannot be demarcated from the underlying brain pathology and has not been studied previously. Recently, we developed rat and mouse models to study SBI and the underlying cellular mechanisms. The animal modeling mimics a neurosurgical operation and causes commonly encountered postoperative complications such as brain edema following blood brain barrier (BBB) disruption, and neuronal cell death. Furthermore, the SBI animal model allows screening of known experimental neuroprotective agents and therapeutic agents being tried in clinical trials as possible pretreatments before neurosurgical procedures. In the present review, we elaborate on SBI and its clinical impact, the SBI animal models and their clinical relevance, and the importance of blanket neuroprotection before neurosurgical procedures.

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