IMR Press / FBL / Volume 12 / Issue 6 / DOI: 10.2741/2208

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Antioxidants decrease reperfusion induced arrhythmias in myocardial infarction with ST-elevation
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1 Laboratorio de Bioquimica Inorganica. Departamento de Investigacion en Bioquímica y Medicina Ambiental, Instituto Nacional de Enfermedades Respiratorias, D.F. Mexico
2 Departamento de Urgencias, Hospital General Centro Medico Nacional La Raza, Instituto Mexicano del Seguro Social, D.F. Mexico
3 Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina del Instituto Politecnico Nacional, D.F. Mexico
Front. Biosci. (Landmark Ed) 2007, 12(6), 2029–2037;
Published: 1 January 2007

In myocardial infarctions with ST-segment elevation, ischemia followed by reperfusion (IR) leads to arrhythmia, myocardial stunning and endothelial dysfunction injury by reactive oxygen species (ROS). To determine the impact of ROS, we examined the effect of antioxidant vitamins on biochemical changes and arrhythmias induced by reperfusion before and after therapeutic thrombolysis (Actilyse®). As compared with those receiving placebo, in individuals who received antioxidants, there was a significant decrease in premature ventricular beats (100% vs 38%), atrial fibrillation (44% vs 6%), ventricular tachycardia (31% vs 0%), first-degree atrial-ventricular block (44% vs 6%), plasma malondialdehyde at the first hour after initiation of thrombolysis (1.07 +/- 0.10 vs 0.53 +/- 0.10 nmols plasma malondialdehyde/mg protein) and circulating neutrophils after 24 hr after reperfusion. The antioxidant capacity of plasma was increased from 1.89 +/- 0.15 to 3.00 +/- 0.31 units/mg protein and paraoxonase-1 rose from 0.77 +/- 0.08 to 1.27 +/- 0.11 nmol/min/mg protein. These findings suggest that antioxidants might be useful as adjuvants in controlling reperfusion induced arrhythmias following therapeutic alteplase thrombolysis.

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