IMR Press / FBL / Volume 10 / Issue 1 / DOI: 10.2741/1553

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Annexins – their role in cartilage mineralization

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1 Musculoskeletal Research Laboratories, Department of Orthopaedics, University of Maryland School of Medicine, 22 S. Greene Street, Baltimore, MD 21201, USA

Academic Editor: Yubo Sun

Front. Biosci. (Landmark Ed) 2005, 10(1), 576–581;
Published: 1 January 2005
(This article belongs to the Special Issue Crystals-associated arthropathies and therapeutic development)

Annexins II, V and VI are highly expressed by hypertrophic and terminally differentiated growth plate chondrocytes and by osteoblasts. Because of the localization of annexins in areas of cartilage and bone mineralization, we hypothesized that these annexins play a regulatory role in the mineralization process. In this article we review the function of annexins II, V and VI in physiological mineralization of skeletal tissues and in pathological mineralization of articular cartilage.

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