Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
Analytical systems integrating in vivo microdialysis sampling with enzyme-based electrochemical biosensor detection have been increasingly accepted to be a new technique for continuous and on-line monitoring of biologically important species. Extensive interests in such integrated on-line analytical systems have suggested that these systems are very useful for physiological and pathological investigations. This review mainly focuses on the principle, development and striking applications of the enzyme-based amperometric biosensors integrated with in vivo microdialysis for continuous and on-line monitoring of cerebral extracellular fluid in recent years.