IMR Press / RCM / Volume 16 / Issue 3 / DOI: 10.3909/ricm0766

Reviews in Cardiovascular Medicine (RCM) is published by IMR Press from Volume 19 Issue 1 (2018). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by IMR Press on as a courtesy and upon agreement with MedReviews, LLC.

Open Access Review
Tricuspid Regurgitation, the Forgotten Valvular Lesion—A Contemporary Review of Etiology, Prevalence, and Management Options
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1 Cedars-Sinai Heart Institute, Los Angeles, CA
2 Department of Medicine, University of Alabama Medical Center, Huntsville, AL
3 Division of Cardiology, VA Greater Los Angeles Healthcare System, Los Angeles, CA
Rev. Cardiovasc. Med. 2015, 16(3), 171–181;
Published: 30 September 2015
Tricuspid regurgitation (TR) is a common finding. Pathologic TR is an independent risk factor for mortality. TR can be classified by etiology into functional versus organic. Organic TR is caused by structural damage to the tricuspid valve (TV) by a spectrum of etiologies, including pacemaker leads and right heart biopsies, whereas functional TR is predominantly due to elevated pulmonary pressures. Atrial fibrillation and chamber enlargement, among other risk factors, are strong predictors of functional TR. Correction of elevated pulmonary pressures improves TR, and concurrent repair of severe TR at the time of left heart valve surgery improves postoperative heart failure symptoms but does not improve survival. TR repair is associated with less operative and long-term mortality than TV replacement, and demonstrates similar improvements in heart failure symptoms. Substantial residual TR remains after repair, and reoperative mortality for residual TR is considerable. Percutaneous TV replacement may offer a rescue strategy.
Tricuspid regurgitation
Tricuspid valve disease
Cardiac surgery
Valvular heart disease
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