Utilizing Spontaneous Ventilation Modes in Patients Underwent Corrective Surgery for Right Ventricular Outflow Tract Obstructive Congenital Heart Disease: A Crossover Study

Xiaolei Gong¹, Limin Zhu¹, Mingjie Zhang¹, Yujie Liu¹, Chunxiang Li¹, Zhuoming Xu^1,*, Jinghao Zheng^2,*

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¹ Cardiac Intensive Care Unit, Department of Thoracic and Cardiovascular Surgery, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, 200127 Shanghai, China

² Department of Thoracic and Cardiovascular Surgery, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, 200127 Shanghai, China

^*Correspondence: zmxyfb@163.com (Zhuoming Xu); zhengjh210@163.com (Jinghao Zheng)

Rev. Cardiovasc. Med. 2023, 24(5), 143; https://doi.org/10.31083/j.rcm2405143

Submitted: 22 November 2022 | Revised: 2 January 2023 | Accepted: 10 January 2023 | Published: 11 May 2023

(This article belongs to the Special Issue Perioperative Management in Cardiac Surgery)

This is an open access article under the CC BY 4.0 license.

Abstract

Background: This study aimed to determine whether the hemodynamics of patients with right ventricle outflow tract obstructive congenital heart disease (RVOTO-CHD) improve after corrective surgery by changing the ventilation mode. Methods: Patients with RVOTO-CHD who underwent corrective surgery were enrolled in this study. Echocardiography and advanced hemodynamic monitoring were performed using the pulse indicator continuous cardiac output (PiCCO) technology in the pressure-regulated volume control (PRVC) mode, followed with switching to the pressure support ventilation (PSV) mode and neurally adjusted ventilatory assist (NAVA) mode in random order. Results: Overall, 31 patients were enrolled in this study from April 2021 to October 2021. Notably, changing the ventilation mode from PRVC to a spontaneous mode (PSV or NAVA) led to better cardiac function outcomes, including right ventricular cardiac index (PRVC: 3.19 $\pm{}$ 1.07 L/min/m ${}^{2}$ vs. PSV: 3.45 $\pm{}$ 1.32 L/min/m ${}^{2}$ vs. NAVA: 3.82 $\pm{}$ 1.03 L/min/m ${}^{2}$ , p $<$ 0.05) and right ventricle contractility (tricuspid annular peak systolic velocity) (PRVC: 6.58 $\pm{}$ 1.40 cm/s vs. PSV: 7.03 $\pm{}$ 1.33 cm/s vs. NAVA: 7.94 $\pm{}$ 1.50 cm/s, p $<$ 0.05), as detected via echocardiography. Moreover, in the NAVA mode, PiCCO-derived cardiac index (PRVC: 2.92 $\pm{}$ 0.54 L/min/m ${}^{2}$ vs. PSV: 3.04 $\pm{}$ 0.56 L/min/m ${}^{2}$ vs. NAVA: 3.20 $\pm{}$ 0.62 L/min/m ${}^{2}$ , p $<$ 0.05), stroke volume index (PRVC: 20.38 $\pm{}$ 3.97 mL/m ${}^{2}$ vs. PSV: 21.23 $\pm{}$ 4.33 mL/m ${}^{2}$ vs. NAVA: 22.00 $\pm{}$ 4.33 mL/m ${}^{2}$ , p $<$ 0.05), and global end diastolic index (PRVC: 295.74 $\pm{}$ 78.39 mL/m ${}^{2}$ vs. PSV: 307.26 $\pm{}$ 91.18 mL/m ${}^{2}$ vs. NAVA: 323.74 $\pm{}$ 102.87 mL/m ${}^{2}$ , p $<$ 0.05) improved, whereas extravascular lung water index significantly reduced (PRVC: 16.42 $\pm{}$ 7.90 mL/kg vs. PSV: 15.42 $\pm{}$ 5.50 mL/kg vs. NAVA: 14.4 $\pm{}$ 4.19 mL/kg, p $<$ 0.05). Furthermore, peak inspiratory pressure, mean airway pressure, driving pressure, and compliance of the respiratory system improved in the NAVA mode. No deaths were reported in this study. Conclusions: We found that utilizing spontaneous ventilator modes, especially the NAVA mode, after corrective surgery in patients with RVOTO-CHD may improve their right heart hemodynamics and respiratory mechanics. However, further randomized controlled trials are required to verify the advantages of spontaneous ventilation modes in such patients. Clinical Trial Registration: NCT04825054.

Keywords

congenital heart disease

mechanical ventilation

cardiac-pulmonary interaction

right ventricle outflow tract obstruction

spontaneous ventilation modes

Funding

YG2019QNA04/The Biomedical and Engineering (Science) Interdisciplinary Study Fund of Shanghai Jiaotong University

YG2019ZDA03/The Biomedical and Engineering (Science) Interdisciplinary Study Fund of Shanghai Jiaotong University

Figures

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