Dear Colleagues,
Lipoprotein receptors are key regulators of neuronal development, synaptic function, and brain homeostasis. Members of the LDL receptor family, including ApoER2, VLDLR, and LDLR, mediate essential signaling pathways that guide neuronal migration, dendritic growth, and synaptic plasticity. These receptors also serve as binding partners for critical ligands such as Reelin and apolipoprotein E (apoE), linking them to processes that underlie learning, memory, and cognitive resilience. Beyond development, alterations in receptor expression, splicing, and signaling contribute to pathological mechanisms in Alzheimer’s disease and related neurodegenerative disorders.
In recent years, advances in structural biology, genetics, and systems neuroscience have greatly expanded our understanding of how lipoprotein receptors integrate extracellular signals to regulate intracellular pathways across the lifespan. This special issue seeks to highlight novel insights into receptor biology, including molecular mechanisms, animal models, and translational perspectives on human disease. We welcome original research articles, reviews, and perspectives addressing lipoprotein receptor function in brain development, synaptic physiology, and neurodegeneration, as well as their potential as therapeutic targets.
Dr. Uwe Beffert
Guest Editor
Manuscripts should be submitted via our online editorial system at https://imr.propub.com by registering and logging in to this website. Once you are registered, click here to start your submission. Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2500 USD. Submitted manuscripts should be well formatted in good English.