IMR Press / FBS / Volume 3 / Issue 1 / DOI: 10.2741/S138

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Transcriptional regulation of bone formation
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1 Department of Molecular Medicine, Cell and Matrix Research Institute, BK21 Medical Education Program for Human Resources, Kyungpook National University School of Medicine, Daegu 700-422, Korea

*Author to whom correspondence should be addressed.

Academic Editor: Cory Xian

Front. Biosci. (Schol Ed) 2011, 3(1), 126–135;
Published: 1 January 2011
(This article belongs to the Special Issue Bone growth, regulation, injury and repair)

Bone formation in vertebrates depends on the proliferation and differentiation of chondrocytes and osteoblasts, which are derived from a mesenchymal precursor cells and are required for skeletal development. This process relies on many transcription factor genes that have functions in bone cell proliferation and differentiation. Over the years, various transcription factors that play essential roles for skeletal formation have been identified in in vivo and/or in vitro molecular and genetic studies. In regulation of bone formation, signaling pathways with these factors have also been established. Major transcription factors including Sox9, Runx2, and Osterix, which are active in chondrocytes or osteoblasts or even in both cells, are indispensable for chondrocyte and/or osteoblast differentiation. Here, the transcriptional regulation of these genes for bone formation will be reviewed on the basis of in vivo mouse models.

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