IMR Press / CEOG / Volume 36 / Issue 4 / pii/1630635897135-1478589513

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Mid-trimester maternal serum markers in predicting adverse pregnancy outcome
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1 Department of Obstetrics and Gynaecology, Physics University of Patras, Medical School, Rion
2 Department of Nuclear Medicine, Physics University of Patras, Medical School, Rion
3 Department of Medical Physics University of Patras, Medical School, Rion (Greece)
Clin. Exp. Obstet. Gynecol. 2009, 36(4), 237–240;
Published: 10 December 2009
Abstract

Objective: In a prospective study, we investigated the association between mid-trimester maternal serum AFP (ms-AFP), maternal serum hCG (ms-hCG) levels and adverse pregnancy outcome in a South-Western Greek population. Materials and Methods: 126 healthy Greek women with spontaneous pregnancies were investigated for ms-AFP and ms-hCG levels between the 13th and 24th weeks of gestation and followed for adverse pregnancy outcome. Abnormal outcomes were considered as ms-AFP levels or ms-hCG levels >2.0 multiples of the median value for gestation (MoM). Statistical analysis was performed by Pearson’s chi-square test. Results: Elevated ms-AFP levels were detected in a total of 25 out of the 126 women studied (19.84%). Elevated ms-hCG levels were detected in a total of ten of the 126 women studied (7.93%). Elevated ms-AFP and ms-hCG levels were detected in a total of four of the 126 women studied (3.17%). Conclusion: Multiparameter testing of placental function in the mid-trimester (uterine artery Doppler, placental morphology, ms-AFP and ms-hCG screening) may allow us to identify women with increased risk of developing severe placental insufficiency and pregnancy complications.
Keywords
Maternal serum markers
AFP levels
hCG levels
Adverse pregnancy outcome
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