IMR Press / CEOG / Volume 26 / Issue 3-4 / pii/1999044

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Open Access Original Research

Relationship between unexplained infertility and human leukocyte antigens and expression of circulating autogeneic and allogeneic antisperm antibodies

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1 Reproductive Medicine Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine, and Maternity Hrnpita/, Kuwait University, Kuwait
Clin. Exp. Obstet. Gynecol. 1999, 26(3-4), 199–202;
Published: 10 September 1999

Purpose: The association between unexplained infertility, human leukocyte antigens (HLA) and expression of circulating antisperm antibodies was studied in 52 couples with unexplained infertility and 15 infertile and 9 fertile couples. Methodology: Evaluation parameters included Terasaki’s HLA microlymphocytotoxicity test, circulating antisperrn antibodies using immunofluorescence technique. Results: Fifty-two couples (8.7%) out of 600 consecutive clinic attendants had unexplained infertility. Unexplained infertility was associated with circulating antisperm antibodies (22 versus 13 and 0% for men and 18.5 versus 13 and 0% for women). HLA class l B6 and B52 and Cw7 and HLA class 2 DR4 and DR6 and sharing of HLA B6, DR4 and DR6 were found more in couples with unexplained infertility. Combined expression of antisperm antibodies by couples, demonstrated more homozygosity for HLA B6 and DR4. Conclusion: Hornozygosity for these antigens, B6, DR4 and DR6, may enhance the expression of antisperm antibodies, and cause infertility.

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