Background and Objective: Haemorrhoids patients frequently experience pain, edema and local inflammation after automatic ligation of haemorrhoids. Reduction in postoperative edema and pain are important factors in postoperative treatment. This study examined the therapeutic efficacy of Shuangjin haemorrhoid ointment with β-sodium aescinate injection in treating postoperative edema and pain in patients with haemorrhoids. Materials and Methods: A total of 150 haemorrhoids patients who received automatic ligation were enrolled in the study. They were randomly assigned to the control group that received routine treatment (75 cases) and the research group that received Shuangjin haemorrhoid ointment and β-sodium aescinate (75 cases). The anal edge edema score, pain score, wound healing time and serum levels of β-endorphin (β-EP) and 5-hydroxytryptamine (5-HT) were compared between the two groups. Results: It was found that the anal edge edema score, pain score and serum levels of β-EP and 5-HT of the research group were statistically lower than the control group both on the fourth and seventh day of treatment (p<0.05). Meanwhile, the length of wound healing time of the research group was statistically shorter than the control group. Conclusion: The combined application of Shuangjin haemorrhoid ointment and β-sodium aescinate has significant benefits in treating anal edge edema and pain after automatic ligation of haemorrhoids.