Purpose: To describe a unique disorder where a transient 6th nerve palsy leading to diploplia following orgasm developed in a 28- year- old woman. This coincided with a weight gain of 100 pounds in a short time without a corresponding change in dietary habits. Materials and Methods: She was treated with the sympathomimetic amine dextroamphetamine sulfate. Results: Indeed she immediately responded to treatment with dextroamphetamine sulfate sustained release capsules with complete resolution of the episodes of 6th nerve palsy following orgasm. Conclusions: The main importance of this case is that it suggests that orgasm causes a transient generalized decrease in sympathetic nervous system activity and that the achievement of an orgasm may require an increase in the sympathetic nervous system activity.