Purpose of investigation: The authors’ aim is to compare surgical outcome of hysteroscopic G1 and G2 submucous myomectomy using bipolar resectoscope to those performed by monopolar device. Materials and Methods: a multicenter-observational-case-control study was conducted on premenopausal women affected by menorrhagia, pelvic pain or infertility because of submucous uterine myoma. The authors considered eligible: single G1 or G2 submucous uterine myoma, at least 0.5 cm ultrasound ‘myometrial-free-margin’ and two months GnRH pre-surgical treatment (myoma > three cm). Goup A patients were treated by bipolar resectoscope and Group B by monopolar resectoscope. Primary endpoint was to compare the groups in term of complete or incomplete myomas resection (“second-stepprocedure” rate). Secondary endpoint was to compare two treatments in term of surgical time and intraoperative complications rate. Results: Group A (60 patients) and Group B (216 patients) were homogeneous for general features and myomas location but they differed for G2 type prevalence (73.3% vs 50.5%), mean myomas diameter (33.17 ± 11.93 vs 29.45 ± 9.63), and surgical time (29.43 ± 12.6 vs 23.2 ± 8.2 minutes). In Group A patients both G1 and G2 myomas were completely removed in single step without intraoperative/ postoperative complications; in Group B surgical outcomes of G1 myomas were similar to those of Group A, while G2 myomas required procedure termination in 12% of cases because of light electrolyte disturbance (22 cases) and severe iponatremia in four cases. All intraoperative complications occurred when procedure time exceeded 30 minutes and when myomas diameter was greater than 37.5 millimeters. Conclusion: in the era of mini-invasive surgery, hysteroscopic approach by bipolar device should be considered as a useful, safe, and large scale feasible procedure for submucosal myoma treatment, particularly when G2.