IMR Press / RCM / Special Issues / 1633676545518

Cardiovascular Benefits of Lifestyle Modification

Submission deadline: 30 April 2022
Special Issue Editors
Osama Hamdy
Clinical Research Division, Joslin Diabetes Center, 1 Joslin Place, Boston, USA; Department of Medicine, Harvard Medical School, Boston, USA
Interests: Effect of short- and long-term weight reduction on cardiovascular risk factors; Medical Nutrition Therapy (MNT) for diabetes and obesity management
Joanna Mitri
Clinical Research Division, Joslin Diabetes Center, 1 Joslin Place, Boston, USA; Department of Medicine, Harvard Medical School, Boston, USA
Interests: Effect of nutrition on lipid profile and cardiovascular risk factors
Special Issue Information

Dear Colleagues,

Cardiovascular disease is the major cause of mortality in the US and across the globe. Multiple cardiovascular risk factors including sedentray lifestyle, centeral obesity, dyslipidemia, hypertension and smoking are mofiable and may reduce cardiovascular mortality. Weight reduction of around 7-10% had been shown to significantly improve insulin sensitivity, reduce systolic and diastolic blood pressure, improve lipid profile; inparticular serum triglycerides and HDL-cholesterol, and enhance endothelial function. These changes in cardiovascular risk factors evantually reduce major adverse cardiovascular events (MACE). However, clinical studies showed contradictory results based on the model of lifestyle intervention. Subclinical inflammation as reflected by increased serum levels of inflamatory cytokines in association with reduction in serum adiponectin are believed to be contributing to insulin resistance, endothelial dysfunction and progression of atherosclerosis. Nutrition and exercise possess a totally independent risk reduction based on nutrition pattern and intensity, type and duration of exercise. Special eating pattern like mediterranean, vegeterian, low carbohydrates, low fat and DASH were shown to be effective in weight and cardiovascular risk reduction. Mulidiciplinary appoarch to intentisve lifestyle modfication was found to be the most successful model, however refinement of each component of lifestyle intervention is still needed in order to achieve the maximal cardiovascular benefits. Meanwhile, behavioral modifications and use of antiobesity medications have been shown to be effective in improving cardiovascular risk factors. The duration and intensity of lifestyle intervention define its effectiveness. Although many programs of lifestyle intervention have been developed and implemented over the last three decades, few of them have been scaled to target larger population. Digital health made it possible to reach more patients throught telehealth and mobile-health and remote tracking devices facilitated follow up. 

Osama Hamdy and Joanna Mitri

Guest Editors

Cardiovascular risk
Myocardial infarction
Manuscript Submission Information

Manuscripts should be submitted via our online editorial system at by registering and logging in to this website. Once you are registered, click here to start your submission Manuscripts can be submitted now or up until the deadline. All papers will go through peer-review process. Accepted papers will be published in the journal (as soon as accepted) and meanwhile listed together on the special issue website. Research articles, reviews as well as short communications are preferred. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office to announce on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts will be thoroughly refereed through a double-blind peer-review process. Please visit the Instruction for Authors page before submitting a manuscript. The Article Processing Charge (APC) in this open access journal is 2200 USD. Submitted papers should be well formatted and use good English.

Planned Paper (2 Papers)
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to IMR Press journals will subject to peer-review before acceptance

Exposure and Exercise Intervention under Hypoxia as a New Hypertension Therapeutic Modality: A Narrative Review

Hun-Young Park

Effects of Circuit Training Program on Cardiovascular Risk Factors, Vascular Inflammatory Markers, and Insulin-like Growth Factor-1 (IGF-1) in Elderly Obese Women with Sarcopenia

Hun-Young Park

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