IMR Press / RCM / Special Issues / 1633676545518

Cardiovascular Benefits of Lifestyle Modification

Submission deadline: 30 April 2022
Special Issue Editors
  • Osama Hamdy
    Clinical Research Division, Joslin Diabetes Center, 1 Joslin Place, Boston, USA,Department of Medicine, Harvard Medical School, Boston, USA
    Interests: Effect of short- and long-term weight reduction on cardiovascular risk factors; Medical Nutrition Therapy (MNT) for diabetes and obesity management
  • Joanna Mitri
    Clinical Research Division, Joslin Diabetes Center, 1 Joslin Place, Boston, USA; Department of Medicine, Harvard Medical School, Boston, USA
    Interests: Effect of nutrition on lipid profile and cardiovascular risk factors
Special Issue Information

Dear Colleagues,

Cardiovascular disease is the major cause of mortality in the US and across the globe. Multiple cardiovascular risk factors including sedentray lifestyle, centeral obesity, dyslipidemia, hypertension and smoking are mofiable and may reduce cardiovascular mortality. Weight reduction of around 7-10% had been shown to significantly improve insulin sensitivity, reduce systolic and diastolic blood pressure, improve lipid profile; inparticular serum triglycerides and HDL-cholesterol, and enhance endothelial function. These changes in cardiovascular risk factors evantually reduce major adverse cardiovascular events (MACE). However, clinical studies showed contradictory results based on the model of lifestyle intervention. Subclinical inflammation as reflected by increased serum levels of inflamatory cytokines in association with reduction in serum adiponectin are believed to be contributing to insulin resistance, endothelial dysfunction and progression of atherosclerosis. Nutrition and exercise possess a totally independent risk reduction based on nutrition pattern and intensity, type and duration of exercise. Special eating pattern like mediterranean, vegeterian, low carbohydrates, low fat and DASH were shown to be effective in weight and cardiovascular risk reduction. Mulidiciplinary appoarch to intentisve lifestyle modfication was found to be the most successful model, however refinement of each component of lifestyle intervention is still needed in order to achieve the maximal cardiovascular benefits. Meanwhile, behavioral modifications and use of antiobesity medications have been shown to be effective in improving cardiovascular risk factors. The duration and intensity of lifestyle intervention define its effectiveness. Although many programs of lifestyle intervention have been developed and implemented over the last three decades, few of them have been scaled to target larger population. Digital health made it possible to reach more patients throught telehealth and mobile-health and remote tracking devices facilitated follow up. 

Osama Hamdy and Joanna Mitri

Guest Editors

Keywords
Lifestyle
Nutrition
Exercise
Cardiovascular risk
Myocardial infarction
Atherosclerosis
Cerebral
Vascular
Dyslipidemia
Hypertension
Obesity
Diabetes
Manuscript Submission Information

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Published Paper (3 Papers)
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