IMR Press / RCM / Volume 8 / Issue S1 / pii/1561094457598-1175887971

Reviews in Cardiovascular Medicine (RCM) is published by IMR Press from Volume 19 Issue 1 (2018). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by IMR Press on as a courtesy and upon agreement with MedReviews, LLC.

Open Access Review
New Drug-Eluting Stent Platforms to Prevent Stent Thrombosis
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1 The Heart Center of Greater Cincinnati and The Lindner Center at The Christ Hospital, Cincinnati, OH; The Ohio State University Department of Medicine and Division of Cardiology, Columbus, OH
Rev. Cardiovasc. Med. 2007, 8(S1), 34–43;
Published: 20 January 2007
Although earlier reports from randomized controlled clinical trials suggested that the incidence of stent thrombosis following drug-eluting stent (DES) implantation was similar to or less than that observed following bare-metal stent deployment, longerterm follow-up has revealed a persistent, protracted risk for thrombosis following DES. This apparent divergence in risk for thrombosis becomes evident beyond 6 to 12 months following deployment. The proposed etiologies of late DES thrombosis are multifactorial and differ somewhat from those factors incriminated in bare-metal stent thrombosis. Prevention strategies are in development to address polymer hypersensitivity/inflammatory response, delayed endothelialization/vessel healing, late incomplete stent apposition, persistence of the underlying endoluminal metal prosthesis, and discontinuation of antiplatelet therapies.
Bare-metal stents
Drug-eluting stents
Stent apposition
Antiplatelet therapies
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