IMR Press / RCM / Volume 8 / Issue 4 / pii/1561094452970-950157093

Reviews in Cardiovascular Medicine (RCM) is published by IMR Press from Volume 19 Issue 1 (2018). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by IMR Press on as a courtesy and upon agreement with MedReviews, LLC.

Open Access Review
Cardiovascular Protection Paradigms: Is Change on the Horizon?
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1 Department of Veterans Affairs and Georgetown University Medical Centers, Washington, DC
Rev. Cardiovasc. Med. 2007, 8(4), 200–213;
Published: 30 December 2007
Recent trials of patients with cardiovascular disease (CVD) have provided a wealth of data regarding diagnosis, risk factors, and treatment. Aggressive risk factor management has been shown to improve patient survival, reduce recurrent events and the need for interventional procedures, and improve the quality of life in patients with known CVD. There have been impressive reductions in blood pressure and low-density lipoprotein cholesterol levels, and improved diabetes control. Medical therapy with options such as angiotensin receptor blockers, angiotensin-converting enzyme inhibitors, and aspirin has been shown to have positive effects. Patients in current trials are more likely to be receiving appropriate treatment upon study entry than were patients in older trials. Changes in the risk profile of high-risk patients have reduced the overall rates of cardiovascular events and will continue to affect outcomes in randomized clinical trials. Such changes should be considered in the design of new clinical trials and in the interpretation of current data.
Cardiovascular disease
Blood pressure
Low-density lipoprotein cholesterol
Angiotensin receptor blockers
Angiotensin-converting enzyme inhibitors
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