IMR Press / RCM / Volume 22 / Issue 4 / DOI: 10.31083/j.rcm2204141
Open Access Review
The role of invasive coronary physiology in Takotsubo Syndrome
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1 Interventional Cardiology Unit, Hospital universitario Lucus Augusti, 27003 Lugo, Galicia, Spain
*Correspondence: (Jeremías Bayón)
Academic Editors: Giuseppe Andò and Francesco Pelliccia
Rev. Cardiovasc. Med. 2021, 22(4), 1357–1360;
Submitted: 26 September 2021 | Revised: 21 October 2021 | Accepted: 1 November 2021 | Published: 22 December 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (

The pathophysiology of Takotsubo Syndrome has not yet been precisely defined. Different hypotheses have been proposed, including cardiotoxicity due to catecholaminergic hormone release, metabolic disorders, coronary microvascular dysfunction and epicardial coronary artery spasm. Invasive coronary physiology is considered the cornerstone to understand physiological assessment of coronary blood flow in this setting. We have reviewed most important studies in coronary invasive physiology in this field to update the state of the art in TakoTsubo Syndrome.

Takotsubo Syndrome
Invasive coronary physiology
Coronary microvascular dysfunction
Fig. 1.
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