IMR Press / RCM / Volume 15 / Issue 2 / DOI: 10.3909/ricm0655

Reviews in Cardiovascular Medicine (RCM) is published by IMR Press from Volume 19 Issue 1 (2018). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by IMR Press on as a courtesy and upon agreement with MedReviews, LLC.

Open Access Review
Global T-wave Inversion on Electrocardiogram: What Is the Differential?
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1 Einstein Heart and Vascular Institute, Einstein Medical Center, Philadelphia, PA
2 Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA
Rev. Cardiovasc. Med. 2014, 15(2), 131–141;
Published: 30 June 2014
Global T-wave inversion as seen on electrocardiogram is associated with a variety of pathophysiologic states, including cardiac, pulmonary, and cerebrovascular disease, and acute electrolyte disorders. Although some of these are chronic conditions, others are acute emergencies, necessitating early diagnosis and treatment. This article reviews and provides examples of possible etiologies of global T-wave inversion on electrocardiogram.
T-wave inversion
Acute cerebrovascular event
Apical hypertrophic cardiomyopathy
Acute pericarditis
Acute myocardial infarction
Pulmonary edema
Pulmonary embolism
Takotsubo cardiomyopathy
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