Background: Sleep apnea is known as a high-risk factor for cardiovascular disease (CVD); However, the influence of apnea on aortic blood pressure and augmentation index (AIx), which cardiac load and independent risks for a future CVD event, remains unclear. Therefore, this study aimed to examine the influence of intermittent normoxic apnea on aortic arterial hemodynamics in healthy men. Methods: Sixteen healthy young men (23 \pm 1.6 years mean \pm SD) underwent the repetitive 20-s apnea with a 40 s interval for 20 min. During the interval, each subject maintained a breath pace at 15 breaths/min. Central hemodynamics were evaluated every 5 min by pulse wave analysis from peripheral (radial) arterial pressure waveforms via general transfer function method and compared among three phases defined as “breath” (for 20 s before apnea), “apnea”, and “rebreathe” (for 20 s after apnea). The baseline values were calculated from the first breathing cycle and compared with each breathing phase every 5 min. Results: Aortic systolic blood pressure and AIx were significantly higher at rebreathe phase than the other phases. Likewise, heart rate and double product (aortic systolic blood pressure \times heart rate) were significantly higher in rebreathe phase than the other phases. Conclusions: These results suggest that cardiac load is increased by intermittent normoxic apnea, especially during the rebreathing phase.