†These authors contributed equally.
Background and objective: This study combined two clinical
indicators (age and prostate volume (PV)) to generate age to PV (AVR) ratio,
whose diagnostic value for prostate cancer (PCa) was examined based on prostate
specific antigen (PSA) in the range of 4–20.0 ng/mL.
Methods: The medical records of patients who underwent transrectal
ultrasound-guided biopsy of the prostate in our hospital from June 2015 to June
2019 were examined retrospectively. According to the pathological results of the
biopsy, the patients were divided into the PCa and benign prostatic hyperplasia
(BPH) groups. Receiver operating characteristic (ROC) curves for TPSA, PSAD, PV,
(F/T)PSA, AVR, and PSA-AV were plotted with SPSS 26.0 and GraphPad Prism 5.0, and
areas under the ROC curves (AUROCs) were determined and compared by Delong test.
A log-linear model was used to compare AVR and other parameters with similar high
sensitivities, for specificity.
Results: The AUROC for AVR was significantly different from those of