IMR Press / JOMH / Volume 18 / Issue 1 / DOI: 10.31083/jomh.2021.053
Open Access Review
The 100 most-cited articles in castration-resistant prostate cancer: a bibliometric analysis
Hui Fang1,2,†Lugeng He3,†Huadong He3Xuliang Wang3Yuyong Wang3Hongwei Ge3Yuehua Wan1,2,*,†Chao Chen3,*,†
Show Less
1 Institute of Information Resource, Zhejiang University of Technology, 310014 Hangzhou, Zhejiang, China
2 Library, Zhejiang University of Technology, 310014 Hangzhou, Zhejiang, China
3 Department of Urology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 310006 Hangzhou, Zhejiang, China
*Correspondence: (Yuehua Wan); (Chao Chen)
These authors contributed equally.
J. Mens. Health 2022, 18(1), 3;
Submitted: 23 February 2021 | Accepted: 9 March 2021 | Published: 17 January 2022
(This article belongs to the Special Issue Therapy and prognosis of metastatic prostate cancer)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Purpose: To assess the present landscape and future research directions, a bibliometric analysis was performed to identify the characteristics of the 100 most-cited articles (T100 articles) on CRPC research. Methods: A list of the T100 articles investigating CRPC was generated by searching the Web of Science (WoS) Core Collection database. Different characteristics of the T100 articles, including the countries/territories, journals, authors, and research areas, were analyzed. Results: The number of citations of T100 articles published between 1992 and 2017 ranged from 282 to 3594, with an average of 654.9 citations. According to the topic of the article, “Mechanisms related to tumor progression or metastasis” ranked first with 41 T100 articles, while immunotherapy ranked fourth with 7 T100 articles. The T100 articles originated from 31 countries, with more than half originating from the USA (n = 89). Professor Scher HI published the most T100 articles as the first author (4) and as the corresponding author (5), while Pro De Bono JS from the Institute of Cancer Research published 3 articles as the first author and 8 articles as the corresponding author. The journal Cancer Research published 20 T100 articles with a total of 8946 citations. The number of T100 articles (r = 0.485, P = 0.01) and the total number of citations (r = 0.626, P < 0.001) were all positively correlated with the IF of the journal. Conclusions: This analysis offers a historical perspective on the progress and attempts to reveal future trends in CRPC research using bibliometric analysis. This study’s results suggest that immunotherapy and the study of androgen receptors as well as their signaling axes will possibly be hot topics and trends in CRPC research.

Castration-resistant prostate cancer (CRPC)
Tumor progression
Bibliometric analysis
Fig. 1.
Back to top