Background: The effect of COVID-19 on the manufacturing industry in China has resulted in increased employee psychological pressure and job insecurity. This study uses a theoretical model to identify the links between job insecurity and life satisfaction, and further explores the multilevel moderating effect underlying these links. Methods: Based on the conservation of resources theory, a hierarchical linear model is utilized to test the relationships among cross-level variables. The data comprises 528 valid questionnaires from 43 manufacturing companies in China. Results: The research results show that both perceived control (individual level) and work–life balance programs (organizational level) positively moderate the relationship between job insecurity and life satisfaction. Conclusions: This study contributes toward identifying the effect of employees’ psychological status and job insecurity on life satisfaction, and further confirms two different level moderators that alleviate the negative relationship between job insecurity and life satisfaction. Whether different genders have an effect on perception of life satisfaction is also considered, and the results show that men perceive significantly greater life satisfaction than women. Finally, based on the research findings, practical and theoretical implications are proposed.