Testosterone is used in the treatment of primary or acquired hypogonadism, constitutional growth retardation, and delayed puberty in male patients. Today, there is a fact that cardiovascular diseases present a high frequency in males with a marked tendency to increase soon. Therefore, the number of men using drugs to treat cardiovascular diseases is increasing rapidly. Cardiovascular drugs, which are frequently used and/or recently introduced, may cause undesirable effects under the heading of drug-drug interaction with testosterone therapy. The number of male patients exposed to these agents may increase rapidly quite soon. In this paper, we reviewed the potential drug-drug interactions between drugs to treat cardiovascular diseases and testosterone treatment considering the pharmacokinetic parameters and experimental animal studies in the literature.
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The interaction of drugs to treat cardiovascular diseases and testosterone therapy, their effects and characteristics
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1
Department of Pharmacology, Kahramanmaras Sütçü Imam University, Faculty of Medicine, 55120 Kahramanmaras, Turkey
2
Department of Cardiology, Kahramanmaras Sütçü Imam University, Faculty of Medicine, 55120 Kahramanmaras, Turkey
*Correspondence: altintasduygun_dr@yahoo.com (Duygun Altıntaş Aykan)
J. Mens. Health 2021, 17(2), 25–31;
https://doi.org/10.31083/jomh.2021.005
Submitted: 22 October 2020 | Accepted: 20 November 2020 | Published: 8 April 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Abstract
Keywords
Testosterone
Drug interactions
Drug-induced
Cardiovascular drugs