COMPARATIVE PHARMACOKINETIC AND BIOAVAILABILITY STUDIES OF MONOTROPEIN, KAEMPFEROL-3-O-GLUCOSIDE, AND QUERCETIN-4’-O-GLUCOSIDE AFTER ORAL AND INTRAVENOUS ADMINISTRATION OF MOTILIPERM IN RATS

Journal of Men’s Health (JOMH) is published by IMR Press from Volume 17 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Dougmar Publishing Group.

Original Research

COMPARATIVE PHARMACOKINETIC AND BIOAVAILABILITY STUDIES OF MONOTROPEIN, KAEMPFEROL-3-O-GLUCOSIDE, AND QUERCETIN-4’-O-GLUCOSIDE AFTER ORAL AND INTRAVENOUS ADMINISTRATION OF MOTILIPERM IN RATS

Bo Ram Choi^1,†, Jae Sung Pyo^2,†, Mi Seon Yeo², Min-Gul Kim³, Yu Seob Shin⁶, Yu Seob Shin¹, Sung Won Lee⁴, Chul Young Kim⁵, Insuk So⁷, Hye Kyung Kim^2,*, Jong Kwan Park^6,*

Show Less

¹ Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea

² College of Pharmacy and Brain Busan 21 program, Kyungsung University, Busan, Republic of Korea

³ Department of Pharmacology, School of Medicine, Jeonbuk National University, Jeonju, Republic of Korea

⁴ Department of Urology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

⁵ College of Pharmacy, Hanyang University, Ansan, Republic of Korea

⁶ Department of Urology, Jeonbuk National University and Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute and Clinical Trial Center of Medical Device of Jeonbuk National University Hospital, Jeonju, Republic of Korea

⁷ Department of Physiology and Biophysics, Seoul National University College of Medicine, Seoul, South Korea

*Author to whom correspondence should be addressed.

† These authors contributed equally.

J. Mens. Health 2020, 16(SP1), 57–70; https://doi.org/10.15586/jomh.v16iSP1.235

Submitted: 3 March 2020 | Accepted: 20 June 2020 | Published: 24 July 2020

Download PDF

Cite

Abstract

Background and Objective

This study has evaluated the pharmacokinetic parameters and bioavailabilities of monotropein, kae-mpferol-3-O-glucoside, and quercetin-4’-O-glucoside after administration of MOTILIPERM in rats.

Material and Methods

Following the administration of MOTILIPERM, the plasma concentrations of each compound in rats were simultaneously determined by using liquid chromatography tandem mass spectrometry (LC-MS/MS).

Results

The pharmacokinetic parameters of monotropein in rats were AUC_inf 20,020.44±3944.67 and 11,915.53±1190.91 min·ng/mL and C_max286.99±38.37 and 56.23±9.02 ng/mL for intravenous and oral administration, respectively. The pharmacokinetic parameters of kaempferol-3-O-glucoside in rats were AUC_inf 287.86±126.17 min·ng/mL and not estimated; C_max 5.80±1.87 and 1.24±0.41 ng/mL for intravenous and oral administration, respectively. The pharmacokinetic parameters of querce-tin-4’-O-glucoside in rats were AUC_inf 511.38±248.11 and 481.44±65.72 min·ng/mL; C_max 10.72±2.70 and 2.83±0.34 ng/mL for intravenous and oral administration, respectively.

Conclusion

The absolute bioavailabilities of monotropein and quercetin-4’-O-glucoside for oral administration were evaluated and calculated as 3.0 and 4.7%, respectively. The absolute bioavailability of kaemp-ferol-3-O-glucoside was not calculated because the elimination rate constant could not be estimated. These results may be applied to the basic data in a further study in order to develop functional foods or herbal medicinal products.

Keywords

bioavailability

kaempferol-3-O-glucoside

monotropein

pharmacokinetic

quercetin-4’-O-glucoside

Previous article in this issue

Next article in this issue

J. Mens. Health Print ISSN 1875-6867 Electronic ISSN 1875-6859