Journal of Men’s Health (JOMH) is published by IMR Press from Volume 17 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Dougmar Publishing Group.
DEPRESSION AUGMENTS THE PRODUCTION OF HIGH-AFFINITY ANTIBODIES AGAINST ESTROGEN METABOLITE-RECEPTOR COMPLEX IN PROSTATE CANCER PATIENTS
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Depression is a common symptom associated with prostate cancer (PC), elevated levels of 16α-hydroxye-strone (16α-OHE1) have been linked to increased risk of PC and estrogen receptor (ER) had been expressed in prostate tissue. This study was carried out to know whether depression augments the production of anti-bodies against 16α-OHE1-ER in PC patients.
Forty-six depressed PC (DPC) (out of total 60 PC) patients and 40 control subjects (who have normal circu-lating prostate-specific antigen [PSA] levels) were checked for the presence of antibodies by ELISA (direct binding and competition) and quantitative precipitin titration.
Antibodies from DPC patients demonstrate high binding to 16α-OHE1-ER in comparison to overall PC patients (p<0.05) and controls (p<0.001). Although, PC sera showed high binding to 16α-OHE1-ER in com-parison to ER (p<0.05) or 16α-OHE1 (p<0.001). The relative affinity of IgGsfrom DPC and PC patients was 1.01×10−7 and 1.19×10−7 M, respectively.
Depression triggers high-affinity antibodies against this antigen in PC patients through inflammatory con-ditions. It also increased the release of pro-inflammatory cytokine (IL-6) that further enhanced antibodies in PC patients.