IMR Press / JOMH / Volume 12 / Issue 1 / DOI: 10.31083/jomh.v12i1.22

Journal of Men’s Health (JOMH) is published by IMR Press from Volume 17 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Dougmar Publishing Group.

Original Research

Dietary Nitrate Supplementation Attenuates Blood Pressure in Young Prehypertensive Men during Exercise

Show Less
1 Members of the Applied Physiology Lab at KyungHee University in Yongin, Republic of Korea
2 Director of the Applied Physiology Lab at KyungHee University in Yongin, Republic of Korea

*Author to whom correspondence should be addressed.

J. Mens. Health 2016, 12(1), 25–33;
Published: 4 January 2016

Background: Acute dietary nitrate (NO3-) supplementation with beetroot juice (BRJ) can lower blood pressure (BP) at rest and during exercise in healthy individuals; however, the effects on endothelial function and BP response to dynamic exercise are not known in prehypertensive individuals. We compared the effects of 15 days BRJ supplementation on hemodynamic responses during progressive dynamic exercise. 

Methods: In a double-blind, randomized, crossover design, 11 healthy, prehypertensive men were supplemented with either BRJ (5.6 mmol, 70 ml BRJ) or a placebo (PL)(70 ml control drink) every day for 15 days. Participants completed two bouts of cycling exercise at each of the two 

workout intensities, corresponding to 30% and 60% of their predetermined VO2peak values. Flow-mediated dilation (FMD) of the brachial artery and plasma concentration of NOx (NO3- and NO2-) were measured, and the mean arterial pressure (MAP), cardiac output (CO), and total vascular conductance (TVC) were assessed at rest and during exercise before and after each treatment. Results: BRJ supplementation significantly increased resting plasma NOx concentrations (123.0±11.3 vs. 181.9±19.5 μM) and the brachial artery FMD (9.8±1.0 vs. 13.5±1.4%) compared to no change after ingestion of the PL. Compared with the PL, BRJ supplementation reduced the MAP (101±1 vs. 99±1 mmHg) at rest and this reduction occurred across workloads, while the TVC was increased only during exercise (p<0.05). There was no difference in CO. 

Conclusions: 15 days of dietary nitrate supplementation could improve endothelial function and contribute to attenuation of an exaggerated exercise BP resulting mainly from a failure to reduce peripheral resistance during exercise.

Beetroot juice
Dynamic exercise
Cardiac output
Endothelial function
Back to top