IMR Press / JIN / Volume 21 / Issue 2 / DOI: 10.31083/j.jin2102072
Open Access Original Research
Gastrodin suppresses pyroptosis and exerts neuroprotective effect in traumatic brain injury model by inhibiting NLRP3 inflammasome signaling pathway
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1 Department of Neurosurgery, The First People’s Hospital of Hefei, 230061 Hefei, Anhui, China
*Correspondence: (Fei Yang)
Academic Editor: Rafael Franco
J. Integr. Neurosci. 2022, 21(2), 72;
Submitted: 12 July 2021 | Revised: 23 August 2021 | Accepted: 2 September 2021 | Published: 24 March 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Traumatic brain injury (TBI), also known as head injury or brain injury, refers to the head injury caused by mechanical impact. It is necessary to develop effective new therapies for TBI injury. Gastrodin (GAS) is the main bioactive ingredient from the rhizome of Gastrodia elata and has significant therapeutic effect on nervous system diseases. However, the protective effects of GAS on brain tissue and related regulatory mechanism in traumatic brain injury remain elusive. Herein, we explored the role of GAS in traumatic brain injury and its related mechanism. We found Gastrodin reduced brain tissue injury and improved functional recovery of injury nerve in TBI rats, and alleviated inflammation. Gastrodin decreased the level of pyroptosis in brain tissue of TBI rats. Further, we found GAS suppressed NLRP3 inflammasome signaling pathway, and therefore suppressed pyroptosis and exerted neuroprotective effect. GAS could serve as a promising drug for TBI treatment.

Traumatic brain injury (TBI)
Gastrodin (GAS)
Fig. 1.
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