IMR Press / JIN / Volume 21 / Issue 1 / DOI: 10.31083/j.jin2101032
Open Access Original Research
No association between myeloperoxidase gene rs2333227 G>A polymorphism and Alzheimer's disease risk: a meta-analysis and trial sequential analysis
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1 Department of Emergency, Taihe Hospital, Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, 442000 Shiyan, Hubei, China
2 Department of Neurology, Taihe Hospital, Hubei University of Medicine, 442000 Shiyan, Hubei, China
3 Department of Stomatology & Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei Key Laboratory of Embryonic Stem Cell Research, Hubei University of Medicine, 442000 Shiyan, Hubei, China
4 Department of Gastroenterology, Shenzhen University General Hospital, Shenzhen University, 518060 Shenzhen, Guangdong, China
*Correspondence: glyang169@gmail.com (Gong-Li Yang); zhoulan123lm@gmail.com (Lan Zhou)
These authors contributed equally.
J. Integr. Neurosci. 2022, 21(1), 32; https://doi.org/10.31083/j.jin2101032
Submitted: 7 April 2021 | Revised: 7 May 2021 | Accepted: 9 August 2021 | Published: 28 January 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Evidence suggests that there is a close association between myeloperoxidase (MPO) gene rs2333227 G>A polymorphism with Alzheimer’s disease (AD) susceptibility. We conducted a meta-analysis to explore the precise association between MPO rs2333227 G>A polymorphism and AD susceptibility. Online databases were searched and the relevant information was collected. Crudeodds ratios with 95% confidence intervals were calculated. Trial sequential analysis (TSA), heterogeneity analyses, accumulative analyses, sensitivity analyses, and publication biasestests were performed. Overall, nine publications (ten independent case-controls) were included in this meta-analysis, involving 3260 participants. Pooled results revealed no significant association between MPO rs2333227 G>A polymorphism and AD susceptibility was observed. TSA showed that the present meta-analysis remained inconclusive due to insufficient evidence. In summary, the current meta-analysis indicated that the MPO rs2333227 G>A polymorphism may not be acausalfactor in the development of AD.

Keywords
Alzheimer's disease
Myeloperoxidase
Polymorphism
Trial sequential analysis
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